Outcomes and predictive factors of successful salvage microdissection testicular sperm extraction (mTESE) after failed classic TESE: results from a multicenter cross-sectional study. in International journal of impotence research / Int J Impot Res. 2022 Dec;34(8):795-799. doi: 10.1038/s41443-021-00487-8. Epub 2021 Nov 6.
2022
AOU Città della Salute di Torino
Tipo pubblicazione
Multicenter Study
Autori/Collaboratori (23)Vedi tutti...
Salonia A
Department of Urology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Montorsi F
Vita-Salute San Raffaele University, Milan, Italy.
Montanari E
Division of Experimental Oncology/Unit of Urology, URI; IRCCS Ospedale San Raffaele, Milan, Italy.
et alii...
Abstract
Microdissection testicular sperm extraction (mTESE) has been proposed as a salvage treatment option for men with a previously failed classic TESE (cTESE), but data are scarce. We aimed to assess the outcome of and potential predictors of successful salvage mTESE in a cohort of men previously submitted to unfruitful cTESE. Data from 61 men who underwent mTESE after a failed cTESE between 01/2014 and 10/2020, at 6 tertiary-referral centres in Italy were analysed. All men were investigated with semen analyses, testicular ultrasound, hormonal and genetic blood testing. Pathological diagnosis from TESE was collected in every man. Descriptive statistics and logistic regression models were used to investigate potential predictors of positive sperm retrieval (SR+) after salvage mTESE. Baseline serum Follicle-Stimulating hormone (FSH) and total testosterone levels were 17.2 (8.6-30.1)?mUI/mL and 4.7 (3.5-6.4) ng/mL, respectively. Sertoli-cell-only syndrome (SCOS), maturation arrest (MA) and hypospermatogenesis were found in 24 (39.3%), 21 (34.4%) and 16 (26.2%) men after cTESE, respectively. At mTESE, SR+ was found in 30 (49.2%) men. Patients with a diagnosis of hypospermatogenesis had a higher rate of SR+ (12/16 (75%)) compared to MA (12/21 (57.1%)) and SCOS (6/24 (25%)) patients at mTESE (p?
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PMID : 34743195
DOI : 10.1038/s41443-021-00487-8
Keywords
Spermatozoa; Semen; Retrospective Studies; Oligospermia; Microdissection/methods; Follicle Stimulating Hormone; Cross-Sectional Studies; Azoospermia/surgery/pathology; Male; Humans;