Radiofrequency catheter ablation of atrial fibrillation: a cause of silent thromboembolism? Magnetic resonance imaging assessment of cerebral thromboembolism in patients undergoing ablation of atrial fibrillation. in Circulation / Circulation. 2010 Oct 26;122(17):1667-73. doi: 10.1161/CIRCULATIONAHA.110.937953. Epub 2010 Oct 11.
2010
ASL Asti
ASL Vercelli
Tipo pubblicazione
Multicenter Study
Autori/Collaboratori (12)Vedi tutti...
Boffano C
Cesarani F
Toso E
et alii...
Abstract
BACKGROUND: Radiofrequency left atrial catheter ablation has become a routine procedure for treatment of atrial fibrillation. The aim of this study was to assess with preprocedural and postprocedural cerebral magnetic resonance imaging the thromboembolic risk, either silent or clinically manifest, in the context of atrial fibrillation ablation. The secondary end point was the identification of clinical or procedural parameters that correlate with cerebral embolism. METHODS AND RESULTS: A total of 232 consecutive patients with paroxysmal or persistent atrial fibrillation who were candidates for radiofrequency left atrial catheter ablation were included in the study. Pulmonary vein isolation or pulmonary vein isolation plus linear lesions plus atrial defragmentation with the use of irrigated-tip ablation catheters was performed. All of the patients underwent preprocedural and postablation cerebral magnetic resonance imaging. A periprocedural symptomatic cerebrovascular accident occurred in 1 patient (0.4). Postprocedural cerebral magnetic resonance imaging was positive for new embolic lesions in 33 patients (14). No clinical parameters such as age, hypertension, diabetes mellitus, previous history of stroke, type of atrial fibrillation, and preablation antithrombotic treatment showed significant correlation with ischemic cerebral embolism. Procedural parameters such as activated clotting time value and, in particular, electric or pharmacological cardioversion to sinus rhythm correlated with an increased incidence of cerebral embolism. Cardioversion was also associated with an increased risk of 2.75 (95 confidence interval, 1.29 to 5.89; P=0.009). CONCLUSIONS: Radiofrequency left atrial catheter ablation carries a low risk of symptomatic cerebral ischemia but is associated with a substantial risk of silent cerebral ischemia detected on magnetic resonance imaging. Independent risk factors for cerebral thromboembolism are the level of activated clotting time and, in particular, the electric or pharmacological cardioversion to sinus rhythm during the procedure.
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PMID : 20937975
DOI : 10.1161/CIRCULATIONAHA.110.937953
Keywords
Magnetic Resonance Imaging; Intracranial Embolism/epidemiology/etiology/pathology; Incidence; Humans; Female; Electric Countershock; Male; Catheter Ablation/adverse effects; Atrial Fibrillation/surgery/therapy; Anticoagulants/therapeutic use; Anti-Arrhythmia Agents/therapeutic use; Aged; Risk Factors; Retrospective Studies; Middle Aged; Prospective Studies;