An Overview of Cellular and Molecular Determinants Regulating Chemoresistance in Pleural Mesothelioma. in Cancers / Cancers (Basel). 2025 Mar 14;17(6):979. doi: 10.3390/cancers17060979.
2025
ASL Città di Torino
Tipo pubblicazione
Review
Autori/Collaboratori (2)
Cortes-Dericks L
Department of Biology, University of Hamburg, 20146 Hamburg, Germany.
Galetta D
Division of Thoracic Surgery, San Giovanni Bosco Hospital, 10154 Turin, Italy.
Abstract
Malignant pleural mesothelioma (PM) is a highly aggressive disease of the lung pleura associated with poor prognosis. Despite advances in improving the clinical management of this malignancy, there is no effective chemotherapy for refractory or relapsing PM. The acquisition of resistance to standard and targeted therapy in this disease is a foremost concern; therefore, a deeper understanding of the complex factors surrounding the emergence of drug resistance is deemed necessary. In this review, we will present broad insights into various cellular and molecular concepts, accounting for the recalcitrance of PM to chemotherapy, including signaling networks regulating drug tolerance, drug resistance-associated proteins, genes, and miRNAs, as well as the critical role of cancer stem cells. Identification of the biological determinants and their associated mechanisms may provide a framework for the development of appropriate treatment.
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PMID : 40149313
DOI : 10.3390/cancers17060979
Keywords
chemoresistance; drug resistance mechanisms; drug-resistant cancer stem cells; malignant pleural mesothelioma;