Influence of sex in alcohol-related liver disease: Pre-clinical and clinical settings. in United European gastroenterology journal / United European Gastroenterol J. 2023 Mar;11(2):218-227. doi: 10.1002/ueg2.12370. Epub 2023 Mar 3.
2023
AOU Città della Salute di Torino
Tipo pubblicazione
Review
Autori/Collaboratori (11)Vedi tutti...
Bizzaro D
Department of Surgery, Oncology, and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padua University Hospital, Padua, Italy.
Becchetti C
Hepatology and Gastroenterology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Trapani S
Italian National Transplant Center, National Institute of Health, Rome, Italy.
et alii...
Abstract
Alcohol-related liver disease (ArLD) is a major cause of chronic liver disease globally. Traditionally, ArLD was mostly a concern in men rather than in women; however, such a sex gap is rapidly narrowing due to increasing chronic alcohol consumption among women. Female sex is more vulnerable to the harmful effects of alcohol with a higher risk of progression to cirrhosis and development of associated complications. The relative risk of cirrhosis and liver-related mortality is significantly higher in women than in men. Our review endeavors to summarize the current knowledge on sex differences in alcohol metabolism, pathogenesis of ArLD, disease progression, indication for liver transplant and pharmacological treatments of ArLD, and provide evidence in support of a sex-specific management of these patients.
Accesso banca dati bibliografica
Accedi alla scheda bibliografica del documento in PUBMED
PMID : 36866682
DOI : 10.1002/ueg2.12370
Keywords
Humans; Female; Male; Liver Diseases/etiology/complications; Liver Cirrhosis/etiology/complications; Liver Transplantation; Ethanol; Risk; alcohol; cirrhosis; gender; portal hypertension; sex;