TORNA ALL’ELENCO

Does mediastinal extension of the goiter increase morbidity of total thyroidectomy? A multicenter study of 19,662 patients in Annals of Surgical Oncology

2011
ASL Torino 4

Tipo pubblicazione

Article

Autori/Collaboratori (19)Vedi tutti...

Testini M
Department of Biomedical Sciences and Human Oncology, Section of General Surgery and Clinical Oncology, University Medical School of Bari, Bari, Italy
Gurrado A
Department of Biomedical Sciences and Human Oncology, Section of General Surgery and Clinical Oncology, University Medical School of Bari, Bari, Italy
Avenia N
Department of Surgery, Thoracic Surgery Unit, University Medical School of Perugia, Perugia, Italy

et alii...

Abstract

Purpose: To compare the outcome in patients with cervical goiters and cervicomediastinal goiters (CMGs) undergoing total thyroidectomy using the cervical or extracervical approach. Methods: This was a retrospective study conducted at six academic departments of general surgery and one endocrine-surgical unit in Italy. The study population consisted of 19,662 patients undergoing total thyroidectomy between 1999 and 2008, of whom 18,607 had cervical goiter (group A) and 1055 had CMG treated using a cervical approach (group B, n = 986) or manubriotomy (group C, n = 69). The main parameters of interest were symptoms, gender, age, operative time, duration of drain, length of hospital stay, malignancy and outcome. Results: A split-sternal approach was required in 6.5% of cases of CMG. Malignancy was significantly more frequent in group B (22.4%) and group C (36.2%) versus group A (10.4%; both P < .001), and in group C versus group B (P = .009). Overall morbidity was significantly higher in groups B + C (35%), B (34.4%) and C (53.5%) versus group A (23.7%; P < .001). Statistically significant increases for group B + C versus group A were observed for transient hypocalcemia, permanent hypocalcemia, transient recurrent laryngeal nerve (RLN) palsies, permanent RLN palsies, phrenic nerve palsy, seroma/hematoma, and complications classified as other. With the exception of transient bilateral RLN palsy, all of these significant differences between group B + C versus group A were also observed for group B versus group A. Conclusions: Symptoms, malignancy, overall morbidity, hypoparathyroidism, RLN palsy and hematoma are increased in cases of substernal goiter. © 2011 Society of Surgical Oncology.

PMID : 21336513

DOI : 10.1245/s10434-011-1596-4

Keywords

adult; age; aged; article; cervicomediastinal goiter; controlled study; disease course; female; gender; goiter; hematoma; human; hypocalcemia; Italy; length of stay; major clinical study; male; mediastinum; morbidity; multicenter study; nerve paralysis; operation duration; phrenic nerve; postoperative complication; recurrent laryngeal nerve palsy; retrospective study; seroma; surgical approach; symptom; thyroid follicular carcinoma; thyroid medullary carcinoma; thyroid papillary carcinoma; thyroidectomy; tracheotomy; treatment outcome;