Association of lower vitamin D levels with inflammation and leucocytes parameters in patients with and without diabetes mellitus undergoing coronary angiography in European Journal of Clinical Investigation
2021
ASL Biella
Tipo pubblicazione
Article
Autori/Collaboratori (10)Vedi tutti...
Verdoia M
Division of Cardiology, Ospedale degli Infermi, ASL Biella, Biella, Italy
Nardin M
Department of Translational Medicine, Eastern Piedmont University, Novara, Italy
Rolla R
Department of Translational Medicine, Eastern Piedmont University, Novara, Italy
et alii...
Abstract
Background: Diabetes mellitus has been associated with a chronic low-grade inflammation and a higher risk of cardiovascular and infectious disease, that could be prevented by the effects of vitamin D. We aimed at evaluating the impact of vitamin D levels on the biomarkers of acute-phase response, inflammation and glucose metabolism in a large cohort of diabetic patients with cardiovascular disease. Materials and methods: Consecutive patients undergoing coronary angiography were included. Diabetes mellitus was defined as previous diagnosis, specific treatment administration (oral drug or insulin), fasting glycaemia >6.99 mmol/L or HbA1c >48 mmol/L. Glucose parameters, white blood cells, Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), C-reactive protein (CRP) and vitamin D were measured at admission. Vitamin D levels were measured by chemiluminescence immunoassay kit LIAISON® Vitamin D assay (Diasorin Inc). Results: We included 1472 diabetic patients and 2499 non-diabetic patients that were divided according to vitamin D tertiles. Among diabetic patients, lower levels of vitamin D were associated with female gender (P =.02), obesity (P =.004), active smoking and acute presentation (P <.001) and with a more atherogenic metabolic profile. The levels of white blood cells, leucocytes subfamilies, and inflammatory parameters significantly correlated with vitamin D levels in both patients with and without diabetes (diabetic: P =.012 for WBC, P =.004 for NLR and P <.001 for MLR and C-reactive protein, non-diabetic: P <.001 for WBC; NLR, MLR and C-reactive protein, respectively). Among diabetic patients, results were confirmed at multivariate analysis with no significant interaction according to glycaemic control. Conclusion: The present study demonstrates that, among patients with cardiovascular disease, vitamin D deficiency is associated with metabolic dysregulation and with an elevation of cellular and humoural inflammatory parameters, esp
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PMID : 33112413
DOI : 10.1111/eci.13439
Keywords
angiographic catheter; angiographic X ray system; blood cell counter; chemiluminescence immunoassay kit; heart catheter; LIAISON; XE2100; biological marker; C reactive protein; glucose; hemoglobin A1c; insulin; vitamin D; acute phase response; adult; aged; article; cardiovascular disease; cohort analysis; coronary angiography; diabetes mellitus; diabetic patient; female; gender; glucose blood level; glucose metabolism; human; inflammation; leukocyte; major clinical study; male; metabolic parameters; monocyte lymphocyte ratio; neutrophil lymphocyte ratio; priority journal; protein blood level; smoking; vitamin blood level; AXIOM ARTIS; Judkins; LIAISON; XE2100;