TORNA ALL’ELENCO

Low-density Lipoprotein cholesterol (LDL-C), Homocysteine (HCY) and C-Reactive Protein (CRP): clinical significance in NSTEMI and STEMI patients differentiated by gender in Biochimica Clinica

2022
ASL Vercelli

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (16)Vedi tutti...

Daffara S
Chemical and Microbiological Lab ASL VC, Vercelli, Italy
Verri E
Faculty of Biological sciences, UNIUPO Alessandria, Italy
Tavano C
Chemical and Microbiological Lab ASL VC, Vercelli, Italy

et alii...

Abstract

OBJECTIVE. Hyperhomocysteinemia has emerged in recent years as an important factor for cardiovascular risk stratification and the definition ischemic patients' conditions associated with other markers (LDL-C and CRP). On top of ECG diagnosis, the dosage of parameters such as HCY and LDL-C strengthen the prognosis of STEMI and NSTEMI conditions.METHODS. LDL-C, HCY and CRP were analyzed in 587 patients admitted in the Cardiology Division of S. Andrea Hospital in Vercelli, from March 2021 to March 2022: 102 patients (73 men and 29 women) belonged to the NSTEMI group, 161 (117 men and 44 women) to the STEMI group and 324 patients with non-ischemic cardiac diseases (212 men and 112 women) were considered as control group (OTHER). Statistical analysis was carried out to assess the significance of the three markers analyzed by Wilcoxon's non-parametric and ANOVA tests.RESULTS. In the overall population the percentages of pathologic values for LDL-C was 40%, for HCY and CRP were respectively 62% and 66%. Significance of LDL-C using Wilcoxon test resulted of p<0.0001 for STEMI vs OTHER and of p= 0.0055 for NSTEMI vs OTHER whereas the returned p-values of the total population for LDL-C were p <0.0001 with ANOVA. HCY produced only a significant p-value (0.0251) in the Wilcoxon test when STEMI was compared with OTHER group. Evaluation of CRP values had no statistical significance. Gender stratification showed a significant difference compared to the total population. In females, p-values for LDL-C and CRP for all three conditions and both tests showed no significance, while HCY had significance in the comparison between STEMI and OTHER with a p-value of 0.028. Otherwise, the male population confirmed the statistical trend for the LDL-C values (ANOVA and Wilcoxon tests). Unlike the total and female populations, the significance for HCY values was absent. CRP showed a mildly significant difference (p = 0.0481) when comparing the STEMI and OTHER populations.CONCLUSION. The

Keywords

C reactive protein; endogenous compound; homocysteine; low density lipoprotein cholesterol; adult; analysis of variance; cardiology; cardiovascular risk; conference abstract; controlled study; electrocardiography; female; gender; heart disease; human; major clinical study; male; non ST segment elevation myocardial infarction; rank sum test; ST segment elevation myocardial infarction; statistical significance;