Italian Association of Hospital Cardiologists Position Paper 'Gender discrepancy: time to implement gender-based clinical management'. in European heart journal supplements : journal of the European Society of Cardiology / Eur Heart J Suppl. 2024 May 16;26(Suppl 2):ii264-ii293. doi: 10.1093/eurheartjsupp/suae034. eCollect
2024
ASL Alessandria
Tipo pubblicazione
Journal Article
Autori/Collaboratori (46)Vedi tutti...
Lucà F
Cardiology Department, Grande Ospedale Metropolitano GOM, Reggio Calabria, Via Melacriono, 1, 89129 Reggio, Calabria, Italy.
Pavan D
Cardio-Cerebro-Rehabilitation Department, Azienda Sanitaria Friuli Occidentale, (AS FO) Via della Vecchia Ceramica, 1, Pordenone 33170, Italy.
Gulizia MM
Cardiology Unit, Cardiology Spoke Cetraro-Paola, San Franceco di paola Hospital, 87027 Paola, CS, Italy.
et alii...
Abstract
It has been well assessed that women have been widely under-represented in cardiovascular clinical trials. Moreover, a significant discrepancy in pharmacological and interventional strategies has been reported. Therefore, poor outcomes and more significant mortality have been shown in many diseases. Pharmacokinetic and pharmacodynamic differences in drug metabolism have also been described so that effectiveness could be different according to sex. However, awareness about the gender gap remains too scarce. Consequently, gender-specific guidelines are lacking, and the need for a sex-specific approach has become more evident in the last few years. This paper aims to evaluate different therapeutic approaches to managing the most common women's diseases.
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PMID : 38784671
DOI : 10.1093/eurheartjsupp/suae034
Keywords
Cardiovascular drugs; Cardiovascular therapy; Gender; Gender differences; Pharmacodynamics; Pharmacokinetics; Sex; Women;