Emerging strategies and clinical recommendations for the management of novel depression subtypes. in Expert review of neurotherapeutics / Expert Rev Neurother. 2025 Feb 27:1-21. doi: 10.1080/14737175.2025.2470973.
2025
AOU San Luigi di Orbassano
Tipo pubblicazione
Review
Autori/Collaboratori (8)Vedi tutti...
Chiappini S
Psychiatry Department, UniCamillus International University of Medical Sciences, Rome, Italy.
Sampogna G
Department of Psychiatry, University of Campania "L. Vanvitelli", Naples, Italy.
Ventriglio A
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
et alii...
Abstract
INTRODUCTION: The phenomenology of depression is characterized by a wide array of emotional, cognitive, and physical symptoms that significantly disrupt an individual's life. Societal changes, driven by technological advancements, economic pressures, environmental concerns including climate change, and shifting cultural norms, have influenced how depression manifests and is understood. These developments have led to the identification of new depression subtypes, highlighting the need for personalized treatment approaches based on individual symptoms and underlying causes. AREAS COVERED: The authors provide a comprehensive narrative review of the literature on managing novel depression subtypes, focusing on both pharmacological and non-pharmacological treatments. Specifically, scenarios recorded were related to i) depression in adolescents and young adults; ii) depression and social disconnection; iii) depression and alcohol/substance use disorder; iv) depression and gender dysphoria; v) depression, stressful events, and other environmental factors. EXPERT OPINION: In the novel depression subtypes discussed, individualized treatment approaches tailored to the individual's specific circumstances are necessary. While selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) remain the cornerstone of treatment for many forms of depression, atypical antidepressants such as trazodone, and emerging therapies like ketamine, neuromodulation techniques, and personalized psychotherapy offer hope for those with complex or treatment-resistant presentations.
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PMID : 40013928
DOI : 10.1080/14737175.2025.2470973
Keywords
Depression; SUD; early-onset depression; gender dysphoria; social disconnection; stress; therapeutic interventions; treatment;