Gender-specific side effects of chemotherapy in pancreatic cancer patients. in Canadian journal of physiology and pharmacology / Can J Physiol Pharmacol. 2022 Apr;100(4):371-377. doi: 10.1139/cjpp-2021-0622. Epub 2021 Oct 21.
2022
ASL Torino 4
AOU Città della Salute di Torino
AOU San Luigi di Orbassano
Tipo pubblicazione
Journal Article
Autori/Collaboratori (12)Vedi tutti...
Mussa MV
Department of Public Health, University of Turin, Città della Salute e della Scienza University Hospital, Turin, Italy.
Ciuffreda L
Department of Public Health, University of Turin, Città della Salute e della Scienza University Hospital, Turin, Italy.
Chiara F
Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
et alii...
Abstract
Pancreatic carcinoma incidence showed a significant increase in men over the last few years and the prognosis remains poor. Patients are treated with different pharmacological plans with no evidence about gender-specific adverse effects. We aimed to investigate differences in the incidence of chemotherapy side effects in the treatment of pancreatic cancer, to provide insights toward a personalized assistance based in individual needs. The sample population is composed of 207 patients. Regression model highlighted the predictive role of female gender for alopecia, constipation, hand-foot syndrome, and epigastric pain. Also, considering single therapeutic schemes, gender differences have been reported. Moreover, evaluating the effect of age, a general reduced risk of toxicity has been reported in younger patients. To personalize chemotherapy and increase patient survival rate and life quality during the therapy, gender medicine and pharmacology studies are recommended.
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PMID : 35104152
DOI : 10.1139/cjpp-2021-0622
Keywords
toxicité médicamenteuse; pancreatic carcinoma; gender differences; effets indésirables; drugs toxicity; différences entre les sexes; chimiothérapie; chemotherapy; cancer du pancreas; adverse effects; Survival Rate; Quality of Life; Male; Pancreatic Neoplasms/drug therapy; Humans; Female; Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use;