Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue. in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA / Knee Surg Sports Traumatol Arthrosc. 2023 Sep;31(9):3655-3664. doi: 10.1007/s00167-022-07139-4. Epub
2023
AOU Città della Salute di Torino
ASL Asti
Tipo pubblicazione
Multicenter Study
Autori/Collaboratori (12)Vedi tutti...
Formica M
Department of General Surgery and Special Surgery, Burns Center Unit, Unit of Skin Bank, Via Zuretti 29, 10126, Turin, Italy.
Alotto D
First University Service, Pathologic Anatomy, Azienda Ospedaliero-Universitaria Città Della Salute, Corso Bramante 88, 10126, Turin, Italy.
Furlan S
Orthopaedic and Traumatology, Cardinal Massaia Hospital, Corso Dante 202, 14100, Asti, Italy.
et alii...
Abstract
PURPOSE: This study aims to assess the effectiveness of Microfragmented Autologous Fat Tissue (MFAT) treatment for knee osteoarthritis and to investigate whether patients' pre-treatment clinical condition, such as synovitis, correlates with clinical outcomes, to identify potential predicting factors for the success or failure of the treatment. METHODS: In this prospective Cohort Study Level II multicentric trial, consecutive patients with a diagnosis of early/mild osteoarthritis and failure of previous conservative measures were enrolled to undergo diagnostic arthroscopy and a single MFAT injection. Patients were assessed with repeated scoring systems at baseline, 6 months, and 12 months after surgery. The demographic features, the arthroscopic findings, the immunophenotype of injected tissue and the histologic examination of synovia of failed patients were analyzed. RESULTS: Data from 91 patients showed a significant improvement in Lysholm, WOMAC scores at 1-year follow-up (p?
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PMID : 36087128
DOI : 10.1007/s00167-022-07139-4
Keywords
Pain; Prospective Studies; Synovitis/etiology/surgery; Treatment Outcome; Adipose tissue-derived mesenchymal stem cells; Knee osteoarthritis; Regenerative medicine; Synovitis; Osteoarthritis, Knee/complications/surgery/pathology; Injections, Intra-Articular; Adipose Tissue; Humans;