Alteration of Volumetric Bone Mineral Density Parameters in Men with Spinal Cord Injury. in Calcified tissue international / Calcif Tissue Int. 2023 Sep;113(3):304-316. doi: 10.1007/s00223-023-01110-2. Epub 2023 Jun 23.
2023
ASL Vercelli
Tipo pubblicazione
Journal Article
Autori/Collaboratori (10)Vedi tutti...
Maïmoun L
Département de Médecine Nucléaire, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France. l-maimoun@chu-montpellier.fr.
Gelis A
Département de Biophysique, Service de Médecine Nucléaire, PhyMedExp, INSERM, CNRS, Université de Montpellier, Hôpital Lapeyronie, 371, Avenue du Doyen Gaston Giraud, 34295, cedex 5, Montpellier, France. l-maimoun@chu-montpellier.fr.
Serrand C
Centre Mutualiste PROPARA, Montpellier, France.
et alii...
Abstract
Spinal cord injury (SCI) induces severe losses of trabecular and cortical volumetric bone mineral density (vBMD), which cannot be discriminated with conventional dual-energy X-ray absorptiometry (DXA) analysis. The objectives were to: (i) determine the effects of SCI on areal BMD (aBMD) and vBMD determined by advanced 3D-DXA-based methods at various femoral regions and (ii) model the profiles of 3D-DXA-derived parameters with the time since injury. Eighty adult males with SCI and 25 age-matched able-bodied (AB) controls were enrolled in this study. Trabecular and cortical vBMD, cortical thickness and derived strength parameters were assessed by 3D-SHAPER® software at various femoral subregions. Individuals with SCI had significantly lower integral vBMD, trabecular vBMD, cortical vBMD, cortical thickness and derived bone strength parameters (p?
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PMID : 37353625
DOI : 10.1007/s00223-023-01110-2
Keywords
3D-SHAPER®; Areal bone mineral density; Cortical bone; Spinal cord injury; Trabecular bone; Volumetric bone mineral density; Absorptiometry, Photon/methods; Bone Density; Humans; Male; Adult; 3D-DXA; Spinal Cord Injuries/complications; Bone and Bones; Femur/pathology;