Can oestrogenic activity in air contribute to the overall body burden of endocrine disruptors? in Environmental toxicology and pharmacology / Environ Toxicol Pharmacol. 2023 Sep;102:104232. doi: 10.1016/j.etap.2023.104232. Epub 2023 Jul 17.

2023
ARPA Piemonte

Tipo pubblicazione

Journal Article

Autori/Collaboratori (7)Vedi tutti...

Gea M
Department of Public Health and Pediatrics, University of Torino, Torino, Italy. Electronic address: marta.gea@unito.it.
Macrì M
Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy.
Marangon D
Regional Agency for Environmental Protection of Piedmont (ARPA Piemonte), Grugliasco, TO, Italy.

et alii...

Abstract

Endocrine disruptors (EDCs) are emerging contaminants that are harmful to health. Human exposure occurs mainly through ingestion or dermal contact, but inhalation could be an additional exposure route; therefore, this study was conducted to evaluate the oestrogenic activity of airborne particulate matter (PM). Outdoor PM was collected for a year in five Italian sites and extracted with organic solvents (four seasonal extracts/site). The oestrogenic activity was assessed using a gene reporter assay (MELN), and the risk to human health through inhalation was quantified using the results. Moreover, extracts were analysed to assess cytotoxicity (WST-1 and LDH assays) on human bronchial cells (BEAS-2B). The extracts induced a significant cytotoxicity and oestrogenic activity. Oestrogenic activity showed a seasonal trend and was correlated with concentrations of benzo(a)pyrene and toxic equivalency factor. Although a low inhalation cancer risk was found, this study confirmed that oestrogenic activity in air could contribute to overall health risks due to EDC exposure.

Accesso banca dati bibliografica

PMID : 37459960

DOI : 10.1016/j.etap.2023.104232

Keywords

Humans; Endocrine Disruptors/toxicity/analysis; Body Burden; Particulate Matter/toxicity/analysis; Italy; Air Pollutants/toxicity/analysis; Cytotoxicity; Endocrine disrupting chemicals; In vitro assay; MELN cells; Particulate matter; Risk assessment;