Incidence and predictors of weaning failure from veno-arterial extracorporeal membrane oxygenation therapy in patients with cardiogenic shock. in European journal of heart failure / Eur J Heart Fail. 2025 Jan 17. doi: 10.1002/ejhf.3583.

2025
AOU Alessandria

Tipo pubblicazione

Journal Article

Autori/Collaboratori (39)Vedi tutti...

Dettling A
Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Kellner C
German Center for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Sundermeyer J
Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.

et alii...

Abstract

AIMS: This study aimed to investigate incidence and predictors of weaning failure and in-hospital death after successful weaning from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock (CS). METHODS AND RESULTS: Overall, 685 patients with CS treated with VA-ECMO from 23 tertiary care centres in 7 countries were analysed (median age 57 [interquartile range 49-66] years, 542 [79.1%] male, median lactate 7.6 [interquartile range 4.1-12.7] mmol/L). The cause of CS was acute myocardial infarction in 438 (63.9%) patients, and 431 (62.9%) patients presented with cardiac arrest. A total of 410 patients (59.9%) were successfully weaned from VA-ECMO, whereas in 275 patients (40.1%) weaning failed (i.e. patients died on or within 48?h after VA-ECMO support). Of the successfully weaned patients, 150 (36.6%) died before hospital discharge. On multivariable logistic regression, predictors for both patient groups varied: age (per 10?years, odds ratio [OR] 1.49, 95% confidence interval [CI] 1.25-1.76; p?