Effect of chemotherapy on cancer specific mortality in female locally advanced urethral cancer. in World journal of urology / World J Urol. 2025 May 4;43(1):266. doi: 10.1007/s00345-025-05545-0.

2025
AOU Novara

Tipo pubblicazione

Journal Article

Autori/Collaboratori (24)Vedi tutti...

Le QC
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada. d.le@med.uni-frankfurt.de.
Peñaranda NR
Department of Urology, Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany. d.le@med.uni-frankfurt.de.
Marmiroli A
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.

et alii...

Abstract

OBJECTIVE: To quantify the effect of chemotherapy (CHT) in locally advanced female primary urethral cancer (fPUC). METHODS: In the Surveillance, Epidemiology and Ends Results (SEER) database (2000-2021), we identified 295 fPUC patients with locally advanced stage treated with local therapy (surgery or radiation or both) with or without CHT. Multivariable Cox regression models addressed cancer specific mortality free survival (CSM). Sample power analyses were computed. RESULTS: Of 295 fPUC patients, 141 (48%) underwent CHT. CHT rates increased from 40 to 61% (?22%) over the study span (2000-2021). Five-year CSM rates of CHT exposed vs. CHT-naïve patients were 58 vs. 43% (?15%). In multivariable Cox regression models (age and histology adjusted) CHT independently predicted lower CSM (HR?=?0.67, p?=?0.027). In squamous cell carcinoma (SCC) subgroup, CHT also independently predicted lower CSM (HR?=?0.64, p?=?0.01). In urothelial carcinoma (HR?=?0.63, p?=?0.2) and adenocarcinoma (HR?=?0.7, p?=?0.7) independent predi

Accesso banca dati bibliografica

PMID : 40320496

DOI : 10.1007/s00345-025-05545-0

Keywords

Humans; Female; Urethral Neoplasms/mortality/drug therapy/pathology; Middle Aged; Aged; Neoplasm Staging; SEER Program; Survival Rate; Retrospective Studies; Carcinoma, Transitional Cell/mortality/drug therapy/pathology; Cancer specific mortality; Chemotherapy; Females; Locally advanced urethral cancer;