Coronary CT angiography alone versus with CT perfusion: a systematic review and meta-analysis assessing approaches for chest pain. in European radiology / Eur Radiol. 2025 Mar 7. doi: 10.1007/s00330-025-11459-7.

2025
AOU Città della Salute di Torino

Tipo pubblicazione

Review

Autori/Collaboratori (26)Vedi tutti...

D'Ascenzo F
Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Turin, Italy.
Faletti R
Department of Radiology, Università degli Studi di Torino, Turin, Italy.
Di Pietro G
Department of Clinical Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

et alii...

Abstract

OBJECTIVES: To evaluate the prognostic value of stress Computed Tomography Perfusion (CTP) in patients with suspected or known coronary artery disease. MATERIALS AND METHODS: All studies evaluating patients with chest pain with CTP plus coronary computed tomography angiography (CCTA) alone or versus CCTA were included. The primary analysis included studies comparing CCTA plus CTP vs CCTA alone, while in the secondary analysis we analyzed the incidence of each outcome across all seven studies, two- and single-arm. RESULTS: Seven double- and single-arm studies were included (two randomized controlled trials and five observational ones) with 3587 patients (2101 evaluated with CTP plus CCTA and 1486 with CCTA alone).In the primary analysis including 4 studies, after a median follow-up of 17 months, the rates of MACEs (OR 1.19, 95% CI 0.91-1.57, p?=?0.21) and all-cause death (OR 0.41, 0.11-1.47, p?=?0.17) were similar. Patients managed according to CCTA alone had higher rates of total ICA (OR 2.42, 1.99-2.94, p?