Changes in adrenomedullin in bronchoalveolar lavage fluid with chorioamnionitis in a sheep-based model. in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians / J Matern Fetal Neonatal Med. 2025 Dec;38(1):2456502. doi: 10.1080/14767058.2025.2456502. Epub 2025 J

2025
ASL Asti

Tipo pubblicazione

Journal Article

Autori/Collaboratori (12)Vedi tutti...

Fabiano A
Neonatal Intensive Care Unit, San Giovanni Addolorata Hospital, Rome, Italy.
Panichi D
Neonatal Intensive Care Unit, Maggiore Hospital, AUSL Bologna, Bologna, Italy.
Picone S
Neonatology and Neonatal Intensive Care Unit, Policlinico Casilino General Hospital, Rome, Italy.

et alii...

Abstract

BACKGROUND: Adrenomedullin (AM) is a potent angiogenic, antioxidant and anti-inflammatory peptide protecting the developing lung from injury due to bronchopulmonary dysplasia (BPD) of the preterm infant. At this stage, no data on the potential effects of chorioamnionitis (CA) occurrence and glucocorticoids (GC) administration on AM in developing lungs are still lacking. OBJECTIVE: to investigate, in a sheep-based model, the positive/side-effects of combined exposure to CA and GC on AM concentrations measured in bronchoalveolar lavage fluid (BALF). METHODS: Time-mated ewes were randomly admitted to one of six treatment groups receiving injection: saline (controls); lipopolysaccharide (L) in intra-amniotic fluid treated alone at 7 or 14 d before delivery or associated with betamethasone (B) intramuscularly; B treated alone (7d) or associated with L (14d). Lambs were surgically delivered at 120?days gestation and euthanized. BALF was used for AM measurement in the studied groups. RESULTS: AM BALF levels significantly (p??0.05) decreased at long-term. The former showed increased AM at short and decreased at long-term (p?