Sex Differences in Procedural Characteristics and Clinical Outcomes Among Patients Undergoing Bifurcation PCI. in Korean circulation journal / Korean Circ J. 2025 Jan;55(1):5-16. doi: 10.4070/kcj.2024.0172. Epub 2024 Oct 11.
2025
ASL Asti
ASL Torino 3
ASL Asti
ASL Torino 3
Tipo pubblicazione
Journal Article
Autori/Collaboratori (32)Vedi tutti...
Hong SJ
Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea.
De Ferrari G
Department of Internal Medicine, Città della Salute e della Scienza, Turin, Italy.
Doh JH
Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
et alii...
Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea.
De Ferrari G
Department of Internal Medicine, Città della Salute e della Scienza, Turin, Italy.
Doh JH
Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
et alii...
Abstract
BACKGROUND AND OBJECTIVES: The risk profiles, procedural characteristics, and clinical outcomes for women undergoing bifurcation percutaneous coronary intervention (PCI) are not well defined compared to those in men. METHODS: COronary BIfurcation Stenting III (COBIS III) is a multicenter, real-world registry of 2,648 patients with bifurcation lesions treated with second-generation drug-eluting stents. We compared the angiographic and procedural characteristics and clinical outcomes based on sex. The primary outcome was 5-year target lesion failure (TLF), a composite of cardiac death, myocardial infarction, and target lesion revascularization. RESULTS: Women (n=635, 24%) were older, had hypertension and diabetes more often, and had smaller main vessel and side branch reference diameters than men. The pre- and post-PCI angiographic percentage diameter stenoses of the main vessel and side branch were comparable between women and men. There were no differences in procedural characteristics between the sexes. Women and men had a similar risk of TLF (6.3% vs. 7.1%, p=0.63) as well as its individual components and sex was not an independent predictor of TLF. This finding was consistent in the left main and 2 stenting subgroups. CONCLUSIONS: In patients undergoing bifurcation PCI, sex was not an independent predictor of adverse outcome. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03068494.
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PMID : 39601395
DOI : 10.4070/kcj.2024.0172
Keywords
Percutaneous coronary intervention; Drug-eluting stents; Coronary vessels; Coronary artery disease; Sex difference;