Biomonitoring of Hydroxylated Polycyclic Aromatic Hydrocarbon Metabolites in Workers at a Waste-to-Energy Incinerator, Turin, Italy. in International journal of environmental research and public health / Int J Environ Res Public Health. 2025 Jan 8;22(1):77. doi: 10.3390/ijerph22010077.

2025
ASL Città di Torino
ASL Torino 3

Tipo pubblicazione

Journal Article

Autori/Collaboratori (11)Vedi tutti...

De Felip E
Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy.
Iacovella N
Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy.
De Luca S
Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy.

et alii...

Abstract

This paper presents the results of the human biomonitoring of ten urinary OH-PAHs (hydroxylated polycyclic aromatic hydrocarbon) in a cohort of workers at an incinerator in Turin, Italy. Long-term exposure was assessed through repeated measurements at three time points: before the startup (T0), after 1 year (T1), and after 3 years (T2). Paired data were available for 26 subjects, seven administrative workers (AWs) and 19 plant workers (PWs). Short-term exposure was assessed by comparing start-end shift measurements. Due to the non-normal distribution of the data, the nonparametric Cuzick's test for trend and the Wilcoxon signed-rank test for paired samples were used. Neither the trend nor the T0-T2 comparison tests resulted in statistically significant outputs in the two groups (q-value > 0.05), even when controlling for smoking habits. In relation to PWs, some of the metabolites were higher at T2 with respect to T0, but no linear increase was found. Conversely, 1-OH-PYR (ng/g creatinine) showed lower median values at T1 (61.5) and T2 (67) compared to the baseline (151.3). Similarly, short-term comparisons yielded no significant results, with rather overlapping distributions of values. Overall, no significant increases in metabolite levels were detected as a result of occupational exposure in the incinerator workers considered. These findings align with previous results for metals and ambient air measurements.

Accesso banca dati bibliografica

PMID : 39857530

DOI : 10.3390/ijerph22010077

Keywords

Environmental Monitoring/methods; Hydroxylation; Air Pollutants, Occupational/analysis/urine; Female; Incineration; Middle Aged; Male; Adult; Biological Monitoring; Occupational Exposure/analysis; Polycyclic Aromatic Hydrocarbons/urine/analysis; Italy; Humans; exposure biomarkers; longitudinal study; occupational exposure; polycyclic aromatic hydrocarbons; waste-to-energy plant;