Prophylactic central neck dissection in differentiated thyroid cancer: risks and benefits in a population with a high rate of tumor recurrence. in Minerva endocrinology / Minerva Endocrinol (Torino). 2025 Mar;50(1):4-14. doi: 10.23736/S2724-6507.22.03892-1. Epub 2022 Sep

2025
ASL Vercelli

Tipo pubblicazione

Journal Article

Autori/Collaboratori (9)Vedi tutti...

Raia M
ENT Division, University of Eastern Piedmont, Novara, Italy.
Mele C
ENT Division, Sant'Andrea Hospital, Vercelli, Italy.
Pagano L
Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy - chiara.mele1989@gmail.com.

et alii...

Abstract

BACKGROUND: The role of prophylactic central neck dissection (pCND) in differentiated thyroid cancer (DTC) is still controversial. METHODS: In a cohort of 274 DTC cN0 patients with a high rate of tumor recurrence, who underwent total thyroidectomy with or without pCND, clinical and histopathological features were retrospectively analyzed. RESULTS: In our cohort, no clinical or histopathological features are able to predict the presence of central lymph node metastases (CLNM) at diagnosis, which instead represents the only variable significantly associated with a higher risk of long-term tumor relapse, independently from age, sex, BMI and radioiodine treatment (OR=1.03, 95% CI: 1.002-1.074, P<0.05). Moreover, our study demonstrates that pCND does not significantly increase the risk of post-surgical complications. CONCLUSIONS: In our setting, pCND could have a key role in the management of DTC. The risks and benefits of pCND should be evaluated for each population to make the most appropriate therapeutic choice.

Accesso banca dati bibliografica

PMID : 36177956

DOI : 10.23736/S2724-6507.22.03892-1

Keywords

Humans; Thyroid Neoplasms/pathology/surgery/radiotherapy; Neck Dissection; Male; Female; Middle Aged; Retrospective Studies; Neoplasm Recurrence, Local/prevention & control; Adult; Thyroidectomy; Aged; Risk Assessment; Lymphatic Metastasis; Young Adult;